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1

Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action

Sheen, Chih‑Wei, Alptürk, Onur, Sluis‑Cremer, Nicolas

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 731 KB

english, 2014

2

Review The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors

Sluis-Cremer, Nicolas

Journal:

Year:

2014

Language:

english

File:

PDF, 594 KB

english, 2014

3

"They just come, pick and go." The Acceptability of Integrated Medication Adherence Clubs for HIV and Non Communicable Disease (NCD) Patients in Kibera, Kenya

Venables, Emilie, Edwards, Jeffrey K., Baert, Saar, Etienne, William, Khabala, Kelly, Bygrave, Helen, Sluis-Cremer, Nicolas

Journal:

Year:

2016

Language:

english

File:

PDF, 935 KB

english, 2016

4

High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium

Guo, Yan, Tomich, Adam D., McElheny, Christi L., Cooper, Vaughn S., Tait-Kamradt, Amelia, Wang, Minggui, Hu, Fupin, Rice, Louis B., Sluis-Cremer, Nicolas, Doi, Yohei

Journal:

Emerging Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 492 KB

english, 2017

5

Naïve CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-Competent HIV-1

Zerbato, Jennifer M, McMahon, Deborah K, Sobolewski, Michelle D, Mellors, John W, Sluis-Cremer, Nicolas

Journal:

Clinical Infectious Diseases

Year:

2019

Language:

english

File:

PDF, 927 KB

english, 2019

6

Peptides Mimicking the Î²7/Î²8 Loop of HIV-1 Reverse Transcriptase p51 as âHotspot-Targetedâ Dimerization Inhibitors

SÃ¡nchez-Murcia, Pedro A., de Castro, Sonia, GarcÃa-Aparicio, Carlos, JimÃ©nez, M. Angeles, Corona, Angela, Tramontano, Enzo, Sluis-Cremer, Nicolas, MenÃ©ndez-Arias, Luis, VelÃ¡zquez, Sonsoles, Gago,

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 2.25 MB

2020

7

ChemInform Abstract: Synthesis and anti-HIV Evaluation of 3′-Triazolo Nucleosides.

Vincent Roy, Aleksandr Obikhod, Hong-Wang Zhang, Steven J. Coats, Brian D. Herman, Nicolas Sluis-Cremer, Luigi A. Agrofoglio, Raymond F. Schinazi

Journal:

Year:

2012

File:

PDF, 23 KB

2012

8

Synthesis and evaluation of 3′-azido-2′,3′-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus

Hong-wang Zhang, Steven J. Coats, Lavanya Bondada, Franck Amblard, Mervi Detorio, Ghazia Asif, Emilie Fromentin, Sarah Solomon, Aleksandr Obikhod, Tony Whitaker, Nicolas Sluis-Cremer, John W. Mellors,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 307 KB

english, 2010

9

Modulation of the oligomeric structures of HIV-1 retroviral enzymes by synthetic peptides and small molecules

Nicolas Sluis-Cremer, Gilda Tachedjian

Journal:

Year:

2002

Language:

english

File:

PDF, 266 KB

english, 2002

10

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase

Jessica Radzio, Nicolas Sluis-Cremer

Journal:

Year:

2011

Language:

english

File:

PDF, 741 KB

english, 2011

11

Conformational stability of pGEX-expressed Schistosoma japonicum glutathione S-transferase: A detoxification enzyme and fusion-protein affinity tag

Warren Kaplan, Julija Erhardt, Nicolas Sluis-Cremer, Heini Dirr, Paul Hüsler, Horst Klump

Journal:

Protein Science

Year:

1997

Language:

english

File:

PDF, 2.17 MB

english, 1997

12

Stereo-selectivity of HIV-1 reverse transcriptase toward isomers of thymidine-5′-O-1-thiotriphosphate

Jessica Radzio, Nicolas Sluis-Cremer

Journal:

Protein Science

Year:

2005

Language:

english

File:

PDF, 155 KB

english, 2005

13

Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses

Qing Xia, Jessica Radzio, Karen S. Anderson, Nicolas Sluis-Cremer

Journal:

Protein Science

Year:

2007

Language:

english

File:

PDF, 460 KB

english, 2007

14

Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides

Hong-wang Zhang, Mervi Detorio, Brian D. Herman, Sarah Solomon, Leda Bassit, James H. Nettles, Aleksandr Obikhod, Si-jia Tao, John W. Mellors, Nicolas Sluis-Cremer, Steven J. Coats, Raymond F. Schinaz

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 962 KB

english, 2011

15

Aflatoxin B1 and sulphobromophthalein binding to the dimeric human glutathione S-transferase A1-1 : a fluorescence spectroscopic analysis

Nicolas Sluis-Cremer, Louise Wallace, Jonathan Burke, Julie Stevens, Heini Dirr

Journal:

Year:

1998

Language:

english

File:

PDF, 265 KB

english, 1998

16

The RNA binding protein HuR does not interact directly with HIV-1 reverse transcriptase and does not affect reverse transcription in vitro

Jinwoo Ahn, In-Ja L Byeon, Sanjeewa Dharmasena, Kelly Huber, Jason Concel, Angela M Gronenborn, Nicolas Sluis-Cremer

Journal:

Year:

2010

Language:

english

File:

PDF, 1.40 MB

english, 2010

17

Determination of a Binding Site for a Non-Substrate Ligand in Mammalian Cytosolic Glutathione S-Transferases by means of Fluorescence-Resonance Energy Transfer

Nicolas Sluis-Cremer, Nirinjini N. Naidoo, Warren H. Kaplan, T. Herbert Manoharan, William E. Fahl, Heini W. Dirr

Journal:

Year:

1996

Language:

english

File:

PDF, 584 KB

english, 1996

18

Class-pi Glutathione S-Transferase is Unable to Regain Its Native Conformation After Oxidative Inactivation by Hydrogen Peroxide

Nicolas Sluis-Cremer, Nirinjini Naidoo, Heini Dirr

Journal:

Year:

1996

Language:

english

File:

PDF, 803 KB

english, 1996

19

Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation

Nicolas Sluis-Cremer, Dominique Arion, Michael E. Abram, Michael A. Parniak

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2004

Language:

english

File:

PDF, 354 KB

english, 2004

20

Conformational stability of Cys45-alkylated and hydrogen peroxide-oxidised glutathione S-transferase

Nicolas Sluis-Cremer, Heini Dirr

Journal:

Year:

1995

Language:

english

File:

PDF, 513 KB

english, 1995

21

Efavirenz enhances the proteolytic processing of an HIV-1 pol polyprotein precursor and reverse transcriptase homodimer formation

Gilda Tachedjian, Katie L. Moore, Stephen P. Goff, Nicolas Sluis-Cremer

Journal:

Year:

2005

Language:

english

File:

PDF, 219 KB

english, 2005

22

Mechanisms of inhibition of HIV replication by non-nucleoside reverse transcriptase inhibitors

Nicolas Sluis-Cremer, Gilda Tachedjian

Journal:

Year:

2008

Language:

english

File:

PDF, 1024 KB

english, 2008

23

In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

Hukezalie, Kyle R., Thumati, Naresh R., Côté, Hélène C. F., Wong, Judy M. Y., Sluis-Cremer, Nicolas

Journal:

Year:

2012

Language:

english

File:

PDF, 911 KB

english, 2012

24

Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides

Roy, Vincent, Obikhod, Aleksandr, Zhang, Hong-Wang, Coats, Steven J., Herman, Brian D., Sluis-Cremer, Nicolas, Agrofoglio, Luigi A., Schinazi, Raymond F.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2011

Language:

english

File:

PDF, 231 KB

english, 2011

25

Structure–activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis

Nicolas Sluis-Cremer, Ellis Kempner, Michael A. Parniak

Journal:

Protein Science

Year:

2003

Language:

english

File:

PDF, 89 KB

english, 2003

26

Radiation Target Analyses of DNA Template/Primer Complexes

Sluis-Cremer, Nicolas, Kempner, Ellis S.

Journal:

Biophysical Journal

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

27

Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimer Destabilization by 1-{Spiro[4‘ ‘-amino-2‘ ‘,2‘ ‘-dioxo-1‘ ‘,2‘ ‘-oxathiole-5‘ ‘,3‘- [2‘,5‘-bis- O -( tert -butyldimethylsilyl)-β- d -ribofuranosyl]]}-3-ethylthymine †

Sluis-Cremer, Nicolas, Dmitrienko, Gary I., Balzarini, Jan, Camarasa, Maria-José, Parniak, Michael A.

Journal:

Year:

2000

Language:

english

File:

PDF, 107 KB

english, 2000

28

Molecular mechanism of HIV-1 resistance to 3′-azido-2′,3′-dideoxyguanosine

Meteer, Jeffrey D., Schinazi, Raymond F., Mellors, John W., Sluis-Cremer, Nicolas

Journal:

Antiviral Research

Year:

2014

Language:

english

File:

PDF, 876 KB

english, 2014

29

E138A in HIV-1 reverse transcriptase is more common in subtype C than B: Implications for rilpivirine use in resource-limited settings

Sluis-Cremer, Nicolas, Jordan, Michael R., Huber, Kelly, Wallis, Carole L., Bertagnolio, Silvia, Mellors, John W., Parkin, Neil T., Richard Harrigan, P.

Journal:

Antiviral Research

Year:

2014

Language:

english

File:

PDF, 397 KB

english, 2014

30

Measurements of the Functional Dynamics of Wild Type and K103N HIV-1 Reverse Transcriptase Reveal the Mechanism of Efavirenz Resistance

Schauer, Grant D., Sluis-Cremer, Nicolas, Leuba, Sanford H.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 80 KB

english, 2013

31

Direct Measurement of HIV-1 Reverse Transcriptase Binding Kinetics, One Complex at a Time

Schauer, Grant D., Sluis-Cremer, Nicolas, Leuba, Sanford H.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 40 KB

english, 2012

32

Equilibrium and Kinetic Unfolding Properties of Dimeric Human Glutathione Transferase A1-1 †

Wallace, Louise A., Sluis-Cremer, Nicolas, Dirr, Heini W.

Journal:

Year:

1998

Language:

english

File:

PDF, 118 KB

english, 1998

33

Structure−Activity Relationships of [2‘,5‘-Bis- O -( tert -butyldimethylsilyl)-β- d -ribofuranosyl]- 3‘-spiro-5‘ ‘-(4‘ ‘-amino-1‘ ‘,2‘ ‘-oxathiole-2‘ ‘,2‘ ‘-dioxide)thymine Derivatives as Inhibitors of HIV-1 Reverse Transcriptase Dimerization

Sluis-Cremer, Nicolas, Hamamouch, Noureddine, San Félix, Ana, Velázquez, Sonsoles, Balzarini, Jan, Camarasa, María-José

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 252 KB

english, 2006

34

Mechanism by which a Glutamine to Leucine Substitution at Residue 509 in the Ribonuclease H Domain of HIV-1 Reverse Transcriptase Confers Zidovudine Resistance †

Brehm, Jessica H., Mellors, John W., Sluis-Cremer, Nicolas

Journal:

Year:

2008

Language:

english

File:

PDF, 2.45 MB

english, 2008

35

Molecular mechanisms of HIV-1 resistance to nucleoside and nucleotide reverse transcriptase inhibitors

Sluis-Cremer, Nicolas

Journal:

Future HIV Therapy

Year:

2007

Language:

english

File:

PDF, 360 KB

english, 2007

36

Identification of mechanistically distinct inhibitors of HIV-1 reverse transcriptase through fragment screening

La, Jennifer, Latham, Catherine F., Tinetti, Ricky N., Johnson, Adam, Tyssen, David, Huber, Kelly D., Sluis-Cremer, Nicolas, Simpson, Jamie S., Headey, Stephen J., Chalmers, David K., Tachedjian, Gild

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 743 KB

english, 2015

37

Novel N-3 Substituted TSAO-T Derivatives: Synthesis and Anti-HIV-Evaluation

Bonache, María-Cruz, Quesada, Ernesto, Sheen, Chih-Wei, Balzarini, Jan, Sluis-Cremer, Nicolas, Pérez-Pérez, María Jesús, Camarasa, María-José, San-Félix, Ana

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2008

Language:

english

File:

PDF, 275 KB

english, 2008

38

Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

Schauer, Grant, Leuba, Sanford, Sluis-Cremer, Nicolas

Journal:

Year:

2013

Language:

english

File:

PDF, 416 KB

english, 2013

39

Editorial [Hot Topic: HIV-1 Reverse Transcriptase Inhibitors: Drug Resistance and Drug Development (Executive Editors: Nicolas Sluis-Cremer and Ted Ross)]

Sluis-Cremer, Nicolas, Ross, Ted

Journal:

Current Pharmaceutical Design

Year:

2006

Language:

english

File:

PDF, 18 KB

english, 2006

40

Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue

Herman, Brian D., Sluis‑Cremer, Nicolas

Journal:

Biochemical Journal

Year:

2013

Language:

english

File:

PDF, 622 KB

english, 2013

41

Impact of Residues in the Nonnucleoside Reverse Transcriptase Inhibitor Binding Pocket on HIV-1 Reverse Transcriptase Heterodimer Stability

Figueiredo, Anna, Zelina, Shannon, Sluis-Cremer, Nicolas, Tachedjian, Gilda

Journal:

Current HIV Research

Year:

2008

Language:

english

File:

PDF, 318 KB

english, 2008

42

Resistance to reverse transcriptase inhibitors used in the treatment and prevention of HIV-1 infection

Sluis-Cremer, Nicolas, Wainberg, Mark A, Schinazi, Raymond F

Journal:

Future Microbiology

Year:

2015

Language:

english

File:

PDF, 1.67 MB

english, 2015

43

Conformational Changes in HIV-1 Reverse Transcriptase Induced by Nonnucleoside Reverse Transcriptase Inhibitor Binding

Sluis-Cremer, Nicolas, Temiz, N., Bahar, Ivet

Journal:

Current HIV Research

Year:

2004

Language:

english

File:

PDF, 407 KB

english, 2004

44

Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase

Parikh, Urvi M, Zelina, Shannon, Sluis-Cremer, Nicolas, Mellors, John W

Journal:

Year:

2007

Language:

english

File:

PDF, 255 KB

english, 2007

45

Failure of Initial Therapy With Two Nucleosides and Efavirenz Is Not Associated With Early Emergence of Mutations in the C-Terminus of HIV-1 Reverse Transcriptase

Brehm, Jessica H, Lalama, Christina M, Hughes, Michael D, Haubrich, Richard, Riddler, Sharon A, Sluis-Cremer, Nicolas, Mellors, John W

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2011

Language:

english

File:

PDF, 98 KB

english, 2011

46

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

Doyon, Geneviève, Zerbato, Jennifer, Mellors, John W., Sluis-Cremer, Nicolas

Journal:

Year:

2013

Language:

english

File:

PDF, 402 KB

english, 2013

47

Glutathione- S -transferase FosA6 of Klebsiella pneumoniae origin conferring fosfomycin resistance in ESBL-producing Escherichia coli

Guo, Qinglan, Tomich, Adam D., McElheny, Christi L., Cooper, Vaughn S., Stoesser, Nicole, Wang, Minggui, Sluis-Cremer, Nicolas, Doi, Yohei

Journal:

Journal of Antimicrobial Chemotherapy

Year:

2016

Language:

english

File:

PDF, 352 KB

english, 2016

48

Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch

Venkatachari, Narasimhan J., Zerbato, Jennifer M., Jain, Siddhartha, Mancini, Allison E., Chattopadhyay, Ansuman, Sluis-Cremer, Nicolas, Bar-Joseph, Ziv, Ayyavoo, Velpandi

Journal:

Year:

2015

Language:

english

File:

PDF, 2.82 MB

english, 2015

49

N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

Sluis-Cremer, Nicolas, Moore, Katie, Radzio, Jessica, Sonza, Secondo, Tachedjian, Gilda

Journal:

Year:

2010

Language:

english

File:

PDF, 446 KB

english, 2010

50

Macrophage-targeted nanocarriers for anti-HIV therapy

Amiji, Mansoor M, Ananworanich, Jintanat, Arrivé, Elise, Sluis-Cremer, Nicolas, Viganò, Alessandra

Journal:

Year:

2007

Language:

english

File:

PDF, 4.80 MB

english, 2007